|Manga Debut||The Heart of a Fire Soldier|
|Anime Debut||The Rookie Fire Soldier Games|
The Powder Medicine (粉薬, Konagusuri) is a powdered substance whereas its main component is the ashes of Infernals. It can be used to induce explosions, powerful enough to force a building's ceiling to collapse, and was given to Joker by Victor Licht. The substance is contained in a bottle, which appears to keep it inactive.